HCID 57589793, compound → HCID 57589800, compound

HRID 1783421Notes

Reaction equation

HRID 1783421 reaction equation
[C:1]([O:5][C:6]([N:8]([C:40]([O:42][C:43]([CH3:46])([CH3:45])[CH3:44])=[O:41])[C:9]1[CH:14]=[C:13]([CH2:15][C@H:16]2[C:19](=[O:20])[N:18]([C:21](=[O:29])[NH:22][C:23]3[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=3)[C@@H:17]2[C:30]([O:32]CC2C=CC=CC=2)=[O:31])[CH:12]=[CH:11][N:10]=1)=[O:7])([CH3:4])([CH3:3])[CH3:2]>CO.C(OCC)(=O)C.[Pd]>[C:43]([O:42][C:40]([N:8]([C:6]([O:5][C:1]([CH3:4])([CH3:3])[CH3:2])=[O:7])[C:9]1[CH:14]=[C:13]([CH2:15][C@H:16]2[C:19](=[O:20])[N:18]([C:21](=[O:29])[NH:22][C:23]3[CH:24]=[CH:25][CH:26]=[CH:27][CH:28]=3)[C@@H:17]2[C:30]([OH:32])=[O:31])[CH:12]=[CH:11][N:10]=1)=[O:41])([CH3:45])([CH3:46])[CH3:44]

Participants

4

Reactant 1

HCID 57589793HCID 57589793, compound

Product 1

HCID 57589800HCID 57589800, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 21584119Ethylacetate methanolSolvent

Procedure

Acylated lactam ester 20 (56 mg, 0.089 mmol) was dissolved in 2 mL of 1:1 methanol-ethyl acetate in a 20 mL glass vial. 10% palladium on carbon catalyst (10 mg) was added, and the solution was stirred under an atmosphere of hydrogen at room temperature overnight under argon, filtered, and then concentrated in vacuo. The residue was pure by HPLC/MS and was taken to the next step without purification. MS: 541.1 [M+H]+.

Workup

  1. filtrationfiltered
  2. concentrationconcentrated in vacuo
  3. customwas taken to the next step without purification

Sources & evidence

ORD record
ord-b2a8676c2be04af68bf78a251ae2b299
Source dataset
uspto-grants-2009_03
Patent number
US07501404B2

Reaction notes

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