Nitric Acid → HCID 178469037, compound

HRID 1783451Notes

Reaction equation

HRID 1783451 reaction equation
[CH2:1]([O:3][C:4](=[O:12])[C:5]1[CH:10]=[CH:9][C:8]([NH2:11])=[CH:7][CH:6]=1)[CH3:2].[N+:13]([O-:16])([OH:15])=[O:14].[N:17]#[C:18][NH2:19]>C(O)C>[N+:13]([O-:16])([OH:15])=[O:14].[CH2:1]([O:3][C:4](=[O:12])[C:5]1[CH:10]=[CH:9][C:8]([NH:11][C:18]([NH2:19])=[NH:17])=[CH:7][CH:6]=1)[CH3:2]

Participants

5

Reactant 3

HCID 944Nitric AcidHCID 2337BenzocaineHCID 9864Cyanamide

Product 1

HCID 178469037HCID 178469037, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

4-aminobenzoic acid ethyl ester (20 g, 0.121 mol), nitric acid (7.26 g, 0.121 mol), cyanamide (50%, 14 ml 0.182 mol) were mixed under reflux with ethanol (50 ml). After 24 hr, the mixture was cooled to RT, and then washed with ethanol to give the titled compound as crystalline solid.

Workup

  1. washwashed with ethanol

Sources & evidence

ORD record
ord-c391bf99df534663a7c96a7ab4abfa3f
Source dataset
uspto-grants-2009_03
Patent number
US07501424B2

Reaction notes

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