4-(4-Pyridin-3-yl-pyrimidin-2-ylamino)-benzoic acid ethyl ester → 4-Methyl-3-[4-(thiazol-2-ylamino)-pyrimidin-2-ylamino]-benzoic acid

HRID 1783460Notes

Reaction equation

HRID 1783460 reaction equation
C([O:3][C:4](=[O:25])[C:5]1[CH:10]=[CH:9][C:8]([CH3:11])=[C:7]([NH:12][C:13]2[N:18]=[C:17]([NH:19][C:20]3[S:21][CH:22]=[CH:23][N:24]=3)[CH:16]=[CH:15][N:14]=2)[CH:6]=1)C.C(OC(=O)C1C=CC(NC2N=C(C3C=NC=CC=3)C=CN=2)=CC=1)C>>[CH3:11][C:8]1[CH:9]=[CH:10][C:5]([C:4]([OH:25])=[O:3])=[CH:6][C:7]=1[NH:12][C:13]1[N:18]=[C:17]([NH:19][C:20]2[S:21][CH:22]=[CH:23][N:24]=2)[CH:16]=[CH:15][N:14]=1

Participants

3

Reactant 2

HCID 143469694-(4-Pyridin-3-yl-pyrimidin-2-ylamino)-benzoic acid ethyl esterHCID 866197534-Methyl-3-[4-(thiazol-2-ylamino)-pyrimidin-2-ylamino]-benzoic acid ethyl ester

Product 1

HCID 866197524-Methyl-3-[4-(thiazol-2-ylamino)-pyrimidin-2-ylamino]-benzoic acid

Procedure

4-methyl-3-[4-(thiazol-2-ylamino)-pyrimidin-2-ylamino]-benzoic acid ethyl ester prepared in Preparation 15 was used instead of 4-(4-pyridin-3-yl-pyrimidin-2-ylamino)-benzoic acid ethyl ester according to the similar procedure to Preparation 19 to give the titled compound as yellow solid.

Sources & evidence

ORD record
ord-01f82e3b9f2b4781b050a0f646eb76bd
Source dataset
uspto-grants-2009_03
Patent number
US07501424B2

Reaction notes

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