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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1783460Generated: October 30, 2026

4-(4-Pyridin-3-yl-pyrimidin-2-ylamino)-benzoic acid ethyl ester → 4-Methyl-3-[4-(thiazol-2-ylamino)-pyrimidin-2-ylamino]-benzoic acid

https://huagongshe.com/reaction/1783460

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-(4-Pyridin-3-yl-pyrimidin-2-ylamino)-benzoic acid ethyl esterHCID 14346969—
Reactant4-Methyl-3-[4-(thiazol-2-ylamino)-pyrimidin-2-ylamino]-benzoic acid ethyl esterHCID 86619753—
Product4-Methyl-3-[4-(thiazol-2-ylamino)-pyrimidin-2-ylamino]-benzoic acidHCID 86619752—

Reaction Steps

4-methyl-3-[4-(thiazol-2-ylamino)-pyrimidin-2-ylamino]-benzoic acid ethyl ester prepared in Preparation 15 was used instead of 4-(4-pyridin-3-yl-pyrimidin-2-ylamino)-benzoic acid ethyl ester according to the similar procedure to Preparation 19 to give the titled compound as yellow solid.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07501424B2
Source datasetuspto-grants-2009_03
ORD IDord-01f82e3b9f2b4781b050a0f646eb76bd
Source noteuspto-grants-2009_03