3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline → N-[3-(2-methylimidazol-1-yl)-5-trifluoromethyl-phenyl]-4-(4-pyridin-3-yl-pyrimidin-2-ylamino)-benzamide

HRID 1783465Notes

Reaction equation

HRID 1783465 reaction equation
[CH3:1][C:2]1[N:3]([C:7]2[CH:8]=[C:9]([NH2:17])[CH:10]=[C:11]([C:13]([F:16])([F:15])[F:14])[CH:12]=2)[CH:4]=[CH:5][N:6]=1.CC1N=CN(C2C=C(N)C=C(C(F)(F)F)C=2)C=1.[N:35]1[CH:40]=[CH:39][CH:38]=[C:37]([C:41]2[CH:46]=[CH:45][N:44]=[C:43]([NH:47][C:48]3[CH:56]=[CH:55][C:51]([C:52](O)=[O:53])=[CH:50][CH:49]=3)[N:42]=2)[CH:36]=1>>[CH3:1][C:2]1[N:3]([C:7]2[CH:8]=[C:9]([NH:17][C:52](=[O:53])[C:51]3[CH:50]=[CH:49][C:48]([NH:47][C:43]4[N:42]=[C:41]([C:37]5[CH:36]=[N:35][CH:40]=[CH:39][CH:38]=5)[CH:46]=[CH:45][N:44]=4)=[CH:56][CH:55]=3)[CH:10]=[C:11]([C:13]([F:16])([F:14])[F:15])[CH:12]=2)[CH:4]=[CH:5][N:6]=1

Participants

4

Reactant 3

HCID 120028253-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)anilineHCID 143469704-(4-(Pyridin-3-yl)pyrimidin-2-ylamino)benzoic acidHCID 667757113-(2-Methyl-1H-imidazole-1-yl)-5-(trifluoromethyl)aniline

Product 1

HCID 68853181N-[3-(2-methylimidazol-1-yl)-5-trifluoromethyl-phenyl]-4-(4-pyridin-3-yl-pyrimidin-2-ylamino)-benzamide

Procedure

3-(2-methyl-imidazol-1-yl)-5 -trifluoromethyl-phenylamine prepared in Preparation 31 was used instead of 3-(4-methyl-imidazol-1-yl)-5-trifluoromethyl-phenylamine and 4-(4-pyridin-3-yl-pyrimidin-2-ylamino)-benzoic acid prepared in Preparation 19 according to the similar procedure to Example 1 to give the titled compound as pale white solid.

Workup

  1. customprepared in Preparation 19 according to the similar procedure to Example 1

Sources & evidence

ORD record
ord-8acb759fb58643299db5704f732afdcc
Source dataset
uspto-grants-2009_03
Patent number
US07501424B2

Reaction notes

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