HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline → N-[3-(2-methylimidazol-1-yl)-5-trifluoromethyl-phenyl]-4-(4-pyridin-3-yl-pyrimidin-2-ylamino)-benzamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline | HCID 12002825 | — |
| Reactant | 4-(4-(Pyridin-3-yl)pyrimidin-2-ylamino)benzoic acid | HCID 14346970 | — |
| Reactant | 3-(2-Methyl-1H-imidazole-1-yl)-5-(trifluoromethyl)aniline | HCID 66775711 | — |
| Product | N-[3-(2-methylimidazol-1-yl)-5-trifluoromethyl-phenyl]-4-(4-pyridin-3-yl-pyrimidin-2-ylamino)-benzamide | HCID 68853181 | — |
Reaction Steps
3-(2-methyl-imidazol-1-yl)-5 -trifluoromethyl-phenylamine prepared in Preparation 31 was used instead of 3-(4-methyl-imidazol-1-yl)-5-trifluoromethyl-phenylamine and 4-(4-pyridin-3-yl-pyrimidin-2-ylamino)-benzoic acid prepared in Preparation 19 according to the similar procedure to Example 1 to give the titled compound as pale white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07501424B2 |
| Source dataset | uspto-grants-2009_03 |
| ORD ID | ord-8acb759fb58643299db5704f732afdcc |
| Source note | uspto-grants-2009_03 |