HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Amino-5-methylthiazole → 4-methyl-N-(5-methylthiazol-2-yl)-3-(4-thiazol-2-yl-pyrimidin-2-ylamino)-benzamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Amino-5-methylthiazole | HCID 351770 | — |
| Reactant | 3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline | HCID 12002825 | — |
| Reactant | 4-(4-(Pyridin-3-yl)pyrimidin-2-ylamino)benzoic acid | HCID 14346970 | — |
| Reactant | 4-Methyl-3-(4-thiazol-2-yl-pyrimidin-2-ylamino)-benzoic acid | HCID 68852864 | — |
| Product | 4-methyl-N-(5-methylthiazol-2-yl)-3-(4-thiazol-2-yl-pyrimidin-2-ylamino)-benzamide | HCID 16063244 | — |
Reaction Steps
4-methyl-3-(4-thiazol-2-yl-pyrimidin-2-ylamino)-benzoic acid and 2-amino-5-methylthiazole were used instead of 4-(4-pyridin-3-yl-pyrimidin-2-ylamino)-benzoic acid and 3-(4-methylimidazol-1-yl)-5-trifluoromethyl-phenylamine according to the similar procedure to Example 5 to give the titled compound as yellow brown solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07501424B2 |
| Source dataset | uspto-grants-2009_03 |
| ORD ID | ord-0a2a9a95fff14f20b484445298ab6fc0 |
| Source note | uspto-grants-2009_03 |