2-Amino-5-methylthiazole → 4-methyl-N-(5-methylthiazol-2-yl)-3-(4-thiazol-2-yl-pyrimidin-2-ylamino)-benzamide

HRID 1783466Notes

Reaction equation

HRID 1783466 reaction equation
[CH3:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([OH:8])=O)=[CH:4][C:3]=1[NH:11][C:12]1[N:17]=[C:16]([C:18]2[S:19][CH:20]=[CH:21][N:22]=2)[CH:15]=[CH:14][N:13]=1.[NH2:23][C:24]1[S:25][C:26]([CH3:29])=[CH:27][N:28]=1.N1C=CC=C(C2C=CN=C(NC3C=CC(C(O)=O)=CC=3)N=2)C=1.CC1N=CN(C2C=C(N)C=C(C(F)(F)F)C=2)C=1>>[CH3:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([NH:23][C:24]2[S:25][C:26]([CH3:29])=[CH:27][N:28]=2)=[O:8])=[CH:4][C:3]=1[NH:11][C:12]1[N:17]=[C:16]([C:18]2[S:19][CH:20]=[CH:21][N:22]=2)[CH:15]=[CH:14][N:13]=1

Participants

5

Reactant 4

HCID 3517702-Amino-5-methylthiazoleHCID 120028253-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)anilineHCID 143469704-(4-(Pyridin-3-yl)pyrimidin-2-ylamino)benzoic acidHCID 688528644-Methyl-3-(4-thiazol-2-yl-pyrimidin-2-ylamino)-benzoic acid

Product 1

HCID 160632444-methyl-N-(5-methylthiazol-2-yl)-3-(4-thiazol-2-yl-pyrimidin-2-ylamino)-benzamide

Procedure

4-methyl-3-(4-thiazol-2-yl-pyrimidin-2-ylamino)-benzoic acid and 2-amino-5-methylthiazole were used instead of 4-(4-pyridin-3-yl-pyrimidin-2-ylamino)-benzoic acid and 3-(4-methylimidazol-1-yl)-5-trifluoromethyl-phenylamine according to the similar procedure to Example 5 to give the titled compound as yellow brown solid.

Sources & evidence

ORD record
ord-0a2a9a95fff14f20b484445298ab6fc0
Source dataset
uspto-grants-2009_03
Patent number
US07501424B2

Reaction notes

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