3-(2-Methyl-1H-imidazole-1-yl)-5-(trifluoromethyl)aniline → 4-methyl-N-[3-(2-methylimidazol-1-yl)-5-trifluoromethyl-phenyl]-3[4-(4-methylimidazol-1-yl)-pyrimidin-2-ylamino]-benzamide

HRID 1783467Notes

Reaction equation

HRID 1783467 reaction equation
[CH3:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([OH:8])=O)=[CH:4][C:3]=1[NH:11][C:12]1[N:17]=[C:16]([N:18]2[CH:22]=[C:21]([CH3:23])[N:20]=[CH:19]2)[CH:15]=[CH:14][N:13]=1.[CH3:24][C:25]1[N:26]([C:30]2[CH:31]=[C:32]([NH2:40])[CH:33]=[C:34]([C:36]([F:39])([F:38])[F:37])[CH:35]=2)[CH:27]=[CH:28][N:29]=1>>[CH3:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([NH:40][C:32]2[CH:33]=[C:34]([C:36]([F:37])([F:38])[F:39])[CH:35]=[C:30]([N:26]3[CH:27]=[CH:28][N:29]=[C:25]3[CH3:24])[CH:31]=2)=[O:8])=[CH:4][C:3]=1[NH:11][C:12]1[N:17]=[C:16]([N:18]2[CH:22]=[C:21]([CH3:23])[N:20]=[CH:19]2)[CH:15]=[CH:14][N:13]=1

Participants

3

Reactant 2

HCID 667757113-(2-Methyl-1H-imidazole-1-yl)-5-(trifluoromethyl)anilineHCID 688511964-Methyl-3-[4-(4-methylimidazol-1-yl)pyrimidin-2-yl-amino]benzoic acid

Product 1

HCID 688524274-methyl-N-[3-(2-methylimidazol-1-yl)-5-trifluoromethyl-phenyl]-3[4-(4-methylimidazol-1-yl)-pyrimidin-2-ylamino]-benzamide

Procedure

4-methyl-3-[4-(4-methylimidazol-1-yl)pyrimidin-2-yl-amino]benzoic acid and 3-(2-methylimidazol-1-yl)-5-trifluoromethyl-phenylamine prepared in Preparation 31 were used according to the similar procedure to Example 1 to give the titled compound as yellow solid.

Sources & evidence

ORD record
ord-25707edd76fc43a589cfa82a58fed9c7
Source dataset
uspto-grants-2009_03
Patent number
US07501424B2

Reaction notes

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