HRID1783467

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID66775711

未命名化合物

结构：Cc1cn(-c2ccnc(Nc3cc(C(=O)O)ccc3C)n2)cn1

HCID68851196

未命名化合物

PRODUCTS

生成物

结构：Cc1cn(-c2ccnc(Nc3cc(C(=O)Nc4cc(-n5ccnc5C)cc(C(F)(F)F)c4)ccc3C)n2)cn1

HCID68852427

未命名化合物

PROCEDURE

实验过程

4-methyl-3-[4-(4-methylimidazol-1-yl)pyrimidin-2-yl-amino]benzoic acid and 3-(2-methylimidazol-1-yl)-5-trifluoromethyl-phenylamine prepared in Preparation 31 were used according to the similar procedure to Example 1 to give the titled compound as yellow solid.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-25707edd76fc43a589cfa82a58fed9c7
来源数据集: uspto-grants-2009_03
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07501424B2
来源说明: uspto-grants-2009_03

反应 SMILES

[CH3:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([OH:8])=O)=[CH:4][C:3]=1[NH:11][C:12]1[N:17]=[C:16]([N:18]2[CH:22]=[C:21]([CH3:23])[N:20]=[CH:19]2)[CH:15]=[CH:14][N:13]=1.[CH3:24][C:25]1[N:26]([C:30]2[CH:31]=[C:32]([NH2:40])[CH:33]=[C:34]([C:36]([F:39])([F:38])[F:37])[CH:35]=2)[CH:27]=[CH:28][N:29]=1>>[CH3:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([NH:40][C:32]2[CH:33]=[C:34]([C:36]([F:37])([F:38])[F:39])[CH:35]=[C:30]([N:26]3[CH:27]=[CH:28][N:29]=[C:25]3[CH3:24])[CH:31]=2)=[O:8])=[CH:4][C:3]=1[NH:11][C:12]1[N:17]=[C:16]([N:18]2[CH:22]=[C:21]([CH3:23])[N:20]=[CH:19]2)[CH:15]=[CH:14][N:13]=1