Trifluoroacetic acid → HCID 66915931, compound

HRID 1783470Notes

Reaction equation

HRID 1783470 reaction equation
C(OC([N:8]1[CH2:12][CH:11]([N:13]2[N:17]=[N:16][C:15]([C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=3)=[N:14]2)[CH2:10][CH:9]1[C:24]([N:26]1[CH2:31][CH2:30][N:29]([C:32]2[CH:37]=[CH:36][CH:35]=[CH:34][C:33]=2[C:38]#[N:39])[CH2:28][CH2:27]1)=[O:25])=O)(C)(C)C.C(O)(C(F)(F)F)=O>>[C:18]1([C:15]2[N:16]=[N:17][N:13]([CH:11]3[CH2:12][NH:8][CH:9]([C:24]([N:26]4[CH2:31][CH2:30][N:29]([C:32]5[CH:37]=[CH:36][CH:35]=[CH:34][C:33]=5[C:38]#[N:39])[CH2:28][CH2:27]4)=[O:25])[CH2:10]3)[N:14]=2)[CH:19]=[CH:20][CH:21]=[CH:22][CH:23]=1

Participants

3

Reactant 2

HCID 6422Trifluoroacetic acidHCID 66915954HCID 66915954, compound

Product 1

HCID 66915931HCID 66915931, compound

Procedure

2-[4-(2-Cyano-phenyl)-piperazine-1-carbonyl]-4-[5-(phenyl)-tetrazol-2-yl]-pyrrolidine-1-carboxylic acid tert-butyl ester (6) is added to CF3COOH, and the reaction mixture is stirred for about 5 h. After removal of CF3COOH, the residue is dissolved in DCM, washed, dried and concentrated to give 2-(4-{4-[5-(phenyl)-tetrazol-2-yl]-pyrrolidine-2-carbonyl}-piperazin-1-yl)-benzonitrile (2).

Workup

  1. customAfter removal of CF3COOH
  2. dissolutionthe residue is dissolved in DCM
  3. washwashed
  4. customdried
  5. concentrationconcentrated

Sources & evidence

ORD record
ord-a2b57657d7144f9e9ef581aa8916d813
Source dataset
uspto-grants-2009_03
Patent number
US07501422B2

Reaction notes

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