Iodine chloride → HCID 57590526, compound

HRID 1783485Notes

Reaction equation

HRID 1783485 reaction equation
[CH2:1]([O:8][C:9]([N:11]1[CH2:16][CH2:15][N:14]([C:17]2[O:18][C:19]3[CH:25]=[CH:24][CH:23]=[CH:22][C:20]=3[N:21]=2)[CH2:13][CH2:12]1)=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[I:26]Cl>C(O)(=O)C>[CH2:1]([O:8][C:9]([N:11]1[CH2:12][CH2:13][N:14]([C:17]2[O:18][C:19]3[CH:25]=[CH:24][C:23]([I:26])=[CH:22][C:20]=3[N:21]=2)[CH2:15][CH2:16]1)=[O:10])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

4

Reactant 2

HCID 24640Iodine chlorideHCID 57590528HCID 57590528, compound

Product 1

HCID 57590526HCID 57590526, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Conditions

Temperature
60 °C

Procedure

A mixture of 4-benzoxazol-2-yl-piperazine-1-carboxylic acid benzyl ester (0.50 g, 1.48 mmol) and iodine monochloride (0.265 g, 1.63 mmol) in acetic acid (4.94 mL) was stirred at 60° C. overnight, cooled, and concentrated in vacuo to provide the title compound, which was used without further purification, in Example 3.

Workup

  1. temperaturecooled
  2. concentrationconcentrated in vacuo

Sources & evidence

ORD record
ord-77e06490c243483cb610fca76a3fdc4f
Source dataset
uspto-grants-2009_03
Patent number
US07501421B2

Reaction notes

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