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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1783503Generated: October 30, 2026

8-Bromo-2-methylquinoline → 2-Methylquinoline-8-carbonitrile

https://huagongshe.com/reaction/1783503

Reaction equation

Participants

RoleNameHCIDCharge
Reactant8-Bromo-2-methylquinolineHCID 4715030—
ReactantHCID 178418546HCID 178418546—
SolventN-methyl-2-pyrrolidoneHCID 13387—
Product2-Methylquinoline-8-carbonitrileHCID 33698227—

Reaction Steps

Prepared by reacting 2-methyl-8-bromo-quinoline with copper(I)cyanide in N-methylpyrrolidinone under a protective gas atmosphere at 180° C.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07501426B2
Source datasetuspto-grants-2009_03
ORD IDord-4e0260fce4ab4fcd8bec6f9e1e1222db
Source noteuspto-grants-2009_03