8-Bromo-2-methylquinoline → 2-Methylquinoline-8-carbonitrile

HRID 1783503Notes

Reaction equation

HRID 1783503 reaction equation
[CH3:1][C:2]1[CH:11]=[CH:10][C:9]2[C:4](=[C:5](Br)[CH:6]=[CH:7][CH:8]=2)[N:3]=1.[Cu][C:14]#[N:15]>CN1CCCC1=O>[CH3:1][C:2]1[CH:11]=[CH:10][C:9]2[C:4](=[C:5]([C:14]#[N:15])[CH:6]=[CH:7][CH:8]=2)[N:3]=1

Participants

4

Reactant 2

HCID 47150308-Bromo-2-methylquinolineHCID 178418546HCID 178418546, compound

Product 1

HCID 336982272-Methylquinoline-8-carbonitrile

Reagents, catalysts & solvents 1

HCID 13387N-methyl-2-pyrrolidoneSolvent

Procedure

Prepared by reacting 2-methyl-8-bromo-quinoline with copper(I)cyanide in N-methylpyrrolidinone under a protective gas atmosphere at 180° C.

Workup

  1. customPrepared
  2. customat 180° C.

Sources & evidence

ORD record
ord-4e0260fce4ab4fcd8bec6f9e1e1222db
Source dataset
uspto-grants-2009_03
Patent number
US07501426B2

Reaction notes

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