Potassium tert-butoxide → HCID 68860000, compound

HRID 1783520Notes

Reaction equation

HRID 1783520 reaction equation
[CH:1]1([N:6]2[C:11]3=[N:12][C:13]([NH:16][C:17]4[CH:22]=[CH:21][C:20]([N:23]5[CH2:28][CH2:27][CH2:26][CH:25]([OH:29])[CH2:24]5)=[CH:19][CH:18]=4)=[N:14][CH:15]=[C:10]3[CH2:9][NH:8][C:7]2=[O:30])[CH2:5][CH2:4][CH2:3][CH2:2]1.CC(C)([O-])C.[K+]>C1COCC1>[CH:1]1([N:6]2[C:11]3=[N:12][C:13]([NH:16][C:17]4[CH:18]=[CH:19][C:20]([N:23]5[CH2:28][CH2:27][CH2:26][CH:25]([OH:29])[CH2:24]5)=[CH:21][CH:22]=4)=[N:14][CH:15]=[C:10]3[CH:9]=[N:8][C:7]2=[O:30])[CH2:2][CH2:3][CH2:4][CH2:5]1

Participants

4

Reactant 2

HCID 23665647Potassium tert-butoxideHCID 53793862HCID 53793862, compound

Product 1

HCID 68860000HCID 68860000, compoundYield 47.8%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

Prepared from 75 mg (0.18 mmol) of 1-cyclopentyl-7-[4-(3-hydroxypiperidin-1-yl)phenylamino]-3,4-dihydro-pyrimido[4,5-d]pyrimidin-2(1H)-one and 82 mg (0.73 mmol) of potassium tert-butoxide in 4.0 mL of THF. The semi-solid residue is triturated in diethyl ether, and the orange amorphous solid is collected and dried to give 35 mg (45%) of the title compound: mp>135° C. (dec).

Workup

  1. customThe semi-solid residue is triturated in diethyl ether
  2. customthe orange amorphous solid is collected
  3. customdried

Sources & evidence

ORD record
ord-0ffbaaa68e8649d6852f4cdccabdf1bb
Source dataset
uspto-grants-2009_03
Patent number
US07501425B1

Reaction notes

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