Trifluoroacetate → HCID 68860282, compound

HRID 1783521Notes

Reaction equation

HRID 1783521 reaction equation
FC(F)(F)C([O-])=O.[CH:8]1([N:13]2[C:18]3=[N:19][C:20]([NH:23][C:24]4[CH:29]=[CH:28][C:27]([N:30]5[CH:34]=[CH:33][CH:32]=[N:31]5)=[CH:26][CH:25]=4)=[N:21][CH:22]=[C:17]3[CH2:16][NH:15][C:14]2=[O:35])[CH2:12][CH2:11][CH2:10][CH2:9]1.CC(C)([O-])C.[K+]>C1COCC1>[CH:8]1([N:13]2[C:18]3=[N:19][C:20]([NH:23][C:24]4[CH:25]=[CH:26][C:27]([N:30]5[CH:34]=[CH:33][CH:32]=[N:31]5)=[CH:28][CH:29]=4)=[N:21][CH:22]=[C:17]3[CH:16]=[N:15][C:14]2=[O:35])[CH2:9][CH2:10][CH2:11][CH2:12]1

Participants

5

Reactant 3

HCID 84468TrifluoroacetateHCID 23665647Potassium tert-butoxideHCID 68858486HCID 68858486, compound

Product 1

HCID 68860282HCID 68860282, compoundYield 40%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

Prepared from 100 mg (0.20 mmol) of the trifluoroacetate salt of 1-cyclopentyl-7-[4-(pyrazol-1-yl)phenylamino]-3,4-dihydro-pyrimido[4,5-d]pyrimidin-2(1H)-one and 115 mg (1.02 mmol) of potassium tert-butoxide in 5.0 mL of THF. The semi-solid residue is triturated in diethyl ether, and the orange amorphous solid is collected and dried to give 31 mg (40%) of the title compound: mp>135° C. (dec).

Workup

  1. customThe semi-solid residue is triturated in diethyl ether
  2. customthe orange amorphous solid is collected
  3. customdried

Sources & evidence

ORD record
ord-06945ac2caeb4eccb18008a0474c2c71
Source dataset
uspto-grants-2009_03
Patent number
US07501425B1

Reaction notes

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