Potassium tert-butoxide → HCID 9951764, compound

HRID 1783522Notes

Reaction equation

HRID 1783522 reaction equation
[CH:1]([N:4]1[C:9]2=[N:10][C:11]([NH:14][C:15]3[CH:20]=[CH:19][C:18]([N:21]4[CH2:26][CH2:25][N:24]([CH3:27])[CH2:23][CH2:22]4)=[CH:17][CH:16]=3)=[N:12][CH:13]=[C:8]2[CH2:7][NH:6][C:5]1=[O:28])([CH3:3])[CH3:2].CC(C)([O-])C.[K+]>O1CCCC1>[CH:1]([N:4]1[C:9]2=[N:10][C:11]([NH:14][C:15]3[CH:16]=[CH:17][C:18]([N:21]4[CH2:26][CH2:25][N:24]([CH3:27])[CH2:23][CH2:22]4)=[CH:19][CH:20]=3)=[N:12][CH:13]=[C:8]2[CH:7]=[N:6][C:5]1=[O:28])([CH3:3])[CH3:2]

Participants

4

Reactant 2

HCID 23665647Potassium tert-butoxideHCID 54308876HCID 54308876, compound

Product 1

HCID 9951764HCID 9951764, compoundYield 68.4%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

Prepared from 200 mg (0.52 mmol) of 1-isopropyl-7-[4-(4-methylpiperazin-1-yl)phenylamino]-3,4-dihydro-pyrimido[4,5-d]pyrimidin-2(1H)-one and 235 mg (2.10 mmol) of potassium tert-butoxide in 10 mL of tetrahydrofuran. The semi-solid is triturated in 14 mL of 1:1 diethyl ether/hexane, and the powder is collected and dried to give 135 mg (68%) of the title compound:

Workup

  1. customThe semi-solid is triturated in 14 mL of 1:1 diethyl ether/hexane
  2. customthe powder is collected
  3. customdried

Sources & evidence

ORD record
ord-ce0bb68876a24fa7a7b71b3091954b4b
Source dataset
uspto-grants-2009_03
Patent number
US07501425B1

Reaction notes

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