Potassium tert-butoxide → HCID 9913534, compound

HRID 1783525Notes

Reaction equation

HRID 1783525 reaction equation
[CH:1]([N:4]1[C:9]2=[N:10][C:11]([NH:14][C:15]3[CH:20]=[CH:19][C:18]([N:21]4[CH2:26][CH2:25][CH:24]([CH2:27][CH2:28][CH2:29][N:30]5[CH2:35][CH2:34][O:33][CH2:32][CH2:31]5)[CH2:23][CH2:22]4)=[CH:17][CH:16]=3)=[N:12][CH:13]=[C:8]2[CH2:7][NH:6][C:5]1=[O:36])([CH3:3])[CH3:2].CC(C)([O-])C.[K+]>O1CCCC1.C(OCC)C>[CH:1]([N:4]1[C:9]2=[N:10][C:11]([NH:14][C:15]3[CH:20]=[CH:19][C:18]([N:21]4[CH2:22][CH2:23][CH:24]([CH2:27][CH2:28][CH2:29][N:30]5[CH2:35][CH2:34][O:33][CH2:32][CH2:31]5)[CH2:25][CH2:26]4)=[CH:17][CH:16]=3)=[N:12][CH:13]=[C:8]2[CH:7]=[N:6][C:5]1=[O:36])([CH3:3])[CH3:2]

Participants

5

Reactant 2

HCID 23665647Potassium tert-butoxide2×HCID 54482822HCID 54482822, compound

Product 1

HCID 9913534HCID 9913534, compoundYield 88.5%

Reagents, catalysts & solvents 2

HCID 3283Diethyl EtherSolventHCID 8028TetrahydrofuranSolvent

Procedure

Prepared from 100 mg (0.20 mmol) of 1-isopropyl-7-{4-[4-(3-(morpholin-4-yl)propyl)piperidin-1-yl]phenylamino}-3,4-dihydro-pyrimido[4,5-d]pyrimidin-2(1H)-one and 88.5 mg (0.79 mmol) of potassium tert-butoxide in 10 mL of tetrahydrofuran. The reaction mixture is stirred overnight, 88.5 mg (0.79 mmol) of potassium tert-butoxide is added, and the reaction is continued for 48 hours. After the workup, the semi-solid is five times suspended in diethyl ether and rotovapped to dryness to give 87 mg (85%) of the title compound: mp>95° C. (dec).

Workup

  1. waitthe reaction is continued for 48 hours

Sources & evidence

ORD record
ord-f63025092e0b449285a8865782de87f3
Source dataset
uspto-grants-2009_03
Patent number
US07501425B1

Reaction notes

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