Potassium tert-butoxide → HCID 9867424, compound

HRID 1783526Notes

Reaction equation

HRID 1783526 reaction equation
[CH:1]12[CH2:7][CH:4]([CH2:5][CH2:6]1)[CH2:3][CH:2]2[N:8]1[C:13]2=[N:14][C:15]([NH:18][C:19]3[CH:24]=[CH:23][C:22]([N:25]4[CH2:30][CH2:29][N:28]([CH3:31])[CH2:27][CH2:26]4)=[CH:21][CH:20]=3)=[N:16][CH:17]=[C:12]2[CH2:11][NH:10][C:9]1=[O:32].CC(C)([O-])C.[K+]>O1CCCC1>[CH:1]12[CH2:7][CH:4]([CH2:5][CH2:6]1)[CH2:3][CH:2]2[N:8]1[C:13]2=[N:14][C:15]([NH:18][C:19]3[CH:20]=[CH:21][C:22]([N:25]4[CH2:26][CH2:27][N:28]([CH3:31])[CH2:29][CH2:30]4)=[CH:23][CH:24]=3)=[N:16][CH:17]=[C:12]2[CH:11]=[N:10][C:9]1=[O:32]

Participants

4

Reactant 2

HCID 23665647Potassium tert-butoxideHCID 54320219HCID 54320219, compound

Product 1

HCID 9867424HCID 9867424, compoundYield 70.5%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

Prepared from 200 mg (0.46 mmol) of 1-bicyclo[2.2.1]hept-2-yl-7-[4-(4-methylpiperazin-1-yl)phenylamino]-3,4-dihydro-pyrimido[4,5-d]pyrimidin-2(1H)-one, exo and 207 mg (1.84 mmol) of potassium tert-butoxide in 10 mL of tetrahydrofuran. The reaction mixture is stirred for 48 hours. After the workup, the semi-solid is triturated in diethyl ether/hexane, and the powder is collected and dried to give 140 mg (70%) of the title compound: mp>210° C. (dec).

Workup

  1. customAfter the workup, the semi-solid is triturated in diethyl ether/hexane
  2. customthe powder is collected
  3. customdried

Sources & evidence

ORD record
ord-47b4f8d2ecf24d84863a2160783fc179
Source dataset
uspto-grants-2009_03
Patent number
US07501425B1

Reaction notes

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