HuagongsheHuagongshe Chemistry Print Report · For research reference only
Bromine → 1-Benzyluracil
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Bromine | HCID 24408 | — |
| Reactant | 1-Benzyl-5-bromo-1,2,3,4-tetrahydropyrimidine-2,4-dione | HCID 5276659 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 1-Benzyluracil | HCID 237962 | — |
Reaction Steps
This experiment was performed to verify the role of DMSO solvent in the generation of the bromine electrophile. Thus, this synthesis was done following the same procedure as for the synthesis of 1-benzyl-5-bromouracil, with the sole exception that DMSO was replaced by dimethylformamide (DMF), as solvent. Extraction was done by water-EtOAc and crystallization was done from EtOAc-Hexanes. After filtration, washing with hexanes and drying under high vacuum, 1.4 g of pure 1-benzyluracil, was isolated, as clean white crystals with properties shown below.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07501429B2 |
| Source dataset | uspto-grants-2009_03 |
| ORD ID | ord-2279370aa0c2485cbfa231929bf5bf2b |
| Source note | uspto-grants-2009_03 |