反应详情

This experiment was performed to verify the role of DMSO solvent in the generation of the bromine electrophile. Thus, this synthesis was done following the same procedure as for the synthesis of 1-benzyl-5-bromouracil, with the sole exception that DMSO was replaced by dimethylformamide (DMF), as solvent. Extraction was done by water-EtOAc and crystallization was done from EtOAc-Hexanes. After filtration, washing with hexanes and drying under high vacuum, 1.4 g of pure 1-benzyluracil, was isolated, as clean white crystals with properties shown below.

1. extractionExtraction
2. customwas done by water-EtOAc and crystallization
3. filtrationAfter filtration
4. washwashing with hexanes
5. dry with materialdrying under high vacuum, 1.4 g of pure 1-benzyluracil
6. customwas isolated, as clean white crystals with properties