Diisopropylethylamine → HCID 178492930, compound

HRID 1783620Notes

Reaction equation

HRID 1783620 reaction equation
CS[C:3]1[S:4][C:5](=[CH:9][C:10]2[CH:11]=[C:12]3[C:17](=[CH:18][CH:19]=2)[N:16]=[CH:15][N:14]=[CH:13]3)[C:6](=[O:8])[N:7]=1.[F:20][C:21]1[CH:27]=[CH:26][C:24]([NH2:25])=[C:23]([O:28][CH3:29])[CH:22]=1.CCN(C(C)C)C(C)C>>[F:20][C:21]1[CH:27]=[CH:26][C:24]([NH:25][C:3]2[S:4]/[C:5](=[CH:9]\[C:10]3[CH:11]=[C:12]4[C:17](=[CH:18][CH:19]=3)[N:16]=[CH:15][N:14]=[CH:13]4)/[C:6](=[O:8])[N:7]=2)=[C:23]([O:28][CH3:29])[CH:22]=1

Participants

4

Reactant 3

HCID 81531DiisopropylethylamineHCID 135322284-Fluoro-2-methoxyanilineHCID 68819203HCID 68819203, compound

Product 1

HCID 178492930HCID 178492930, compound

Procedure

Similar procedure as described in example 1d was used, starting from 2-methylsulfanyl-5-quinazolin-6-ylmethylene-thiazol-4-one, 4-fluoro-2-methoxy-aniline and DIEA to give 2-(4-fluoro-2-methoxy-phenylamino)-5-[1-quinazolin-6-yl-meth-(Z)-ylidene]-thiazol-4-one: LC-MS m/e observed. LC-MS m/e 381 (MH+).

Sources & evidence

ORD record
ord-9c86364f61f844208660d6212207cf6f
Source dataset
uspto-grants-2009_03
Patent number
US07501428B2

Reaction notes

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