3-Fluoroaniline → HCID 178517997, compound

HRID 1783621Notes

Reaction equation

HRID 1783621 reaction equation
CS[C:3]1[S:4][C:5](=[CH:9][C:10]2[CH:11]=[C:12]3[C:17](=[CH:18][CH:19]=2)[N:16]=[CH:15][N:14]=[CH:13]3)[C:6](=[O:8])[N:7]=1.[F:20][C:21]1[CH:22]=[C:23]([CH:25]=[CH:26][CH:27]=1)[NH2:24].CCN(C(C)C)C(C)C>>[F:20][C:21]1[CH:22]=[C:23]([NH:24][C:3]2[S:4]/[C:5](=[CH:9]\[C:10]3[CH:11]=[C:12]4[C:17](=[CH:18][CH:19]=3)[N:16]=[CH:15][N:14]=[CH:13]4)/[C:6](=[O:8])[N:7]=2)[CH:25]=[CH:26][CH:27]=1

Participants

4

Reactant 3

HCID 97423-FluoroanilineHCID 81531DiisopropylethylamineHCID 68819203HCID 68819203, compound

Product 1

HCID 178517997HCID 178517997, compound

Procedure

Similar procedure as described in example 1d was used, starting from 2-methylsulfanyl-5-quinazolin-6-ylmethylene-thiazol-4-one, 3-fluoroaniline and DIEA to give 2-(3-fluoro-phenylamino)-5-[1-quinazolin-6-yl-meth-(Z)-ylidene]-thiazol-4-one: LC-MS m/e observed. LC-MS m/e 351 (MH+).

Sources & evidence

ORD record
ord-d6657e347a6b4e529294c0b83410d5fe
Source dataset
uspto-grants-2009_03
Patent number
US07501428B2

Reaction notes

Loading…