3-Fluorobenzylamine → HCID 178518091, compound

HRID 1783622Notes

Reaction equation

HRID 1783622 reaction equation
CS[C:3]1[S:4][C:5](=[CH:9][C:10]2[CH:11]=[C:12]3[C:17](=[CH:18][CH:19]=2)[N:16]=[CH:15][N:14]=[CH:13]3)[C:6](=[O:8])[N:7]=1.[F:20][C:21]1[CH:22]=[C:23]([CH:26]=[CH:27][CH:28]=1)[CH2:24][NH2:25].CCN(C(C)C)C(C)C>>[F:20][C:21]1[CH:22]=[C:23]([CH:26]=[CH:27][CH:28]=1)[CH2:24][NH:25][C:3]1[S:4]/[C:5](=[CH:9]\[C:10]2[CH:11]=[C:12]3[C:17](=[CH:18][CH:19]=2)[N:16]=[CH:15][N:14]=[CH:13]3)/[C:6](=[O:8])[N:7]=1

Participants

4

Reactant 3

HCID 668533-FluorobenzylamineHCID 81531DiisopropylethylamineHCID 68819203HCID 68819203, compound

Product 1

HCID 178518091HCID 178518091, compound

Procedure

Similar procedure as described in example 1d was used, starting from 2-methylsulfanyl-5-quinazolin-6-ylmethylene-thiazol-4-one, 3-fluoro-benzylamine and DIEA to give 2-(3-fluoro-benzylamino)-5-[1-quinazolin-6-yl-meth-(Z)-ylidene]-thiazol-4-one: LC-MS m/e observed. LC-MS m/e 379 (MH+).

Sources & evidence

ORD record
ord-57163b1f79a04964992eba5ffa026e39
Source dataset
uspto-grants-2009_03
Patent number
US07501428B2

Reaction notes

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