反应详情

The mixture of 4-ethoxy-quinazoline-6-carbaldehyde (example 10b, 20 mg, 0.1 mmol,), 2-[2-(3-Fluoro-phenyl)-ethylamino]-thiazol-4-one (example 10c, 24 mg, 0.1 mmol) and piperidine (10 ul, 0.1 mmol) in anhydrous ethyl alcohol (1 ml) was microwaved at 160° C. for 25 min. After cooling the reaction to room temperature, the solid was collected by filtration, then washed with MeOH and dried to afford 5-[1-(4-ethoxy-quinazolin-6-yl)-meth-(Z)-ylidene]-2-[2-(3-fluoro-phenyl)-ethylamino]-thiazol-4-one (12 mg, 30%) as light yellow solid. LC-MS m/e 423 (MH+).

1. customwas microwaved at 160° C. for 25 min
2. temperatureAfter cooling
3. customthe reaction to room temperature
4. filtrationthe solid was collected by filtration
5. washwashed with MeOH
6. customdried