Diisopropylethylamine → HCID 178516941, compound

HRID 1783639Notes

Reaction equation

HRID 1783639 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([CH:7]=[CH:8][C:9]=1[F:10])[CH2:5][NH2:6].[S:11]1[CH2:17][C:15](=[O:16])[NH:14][C:12]1=S.CCN(C(C)C)C(C)C>>[Cl:1][C:2]1[CH:3]=[C:4]([CH:7]=[CH:8][C:9]=1[F:10])[CH2:5][NH:6][C:12]1[S:11][CH2:17][C:15](=[O:16])[N:14]=1

Participants

4

Reactant 3

HCID 81531DiisopropylethylamineHCID 1445393-Chloro-4-fluorobenzylamineHCID 1201546Rhodanine

Product 1

HCID 178516941HCID 178516941, compound

Procedure

Similar procedure as described in example 15a was used, starting with 3-chloro-4-fluoro-benzylamine, rhodanine, mercuric chloride and DIEA to give 2-(3-chloro-4-fluoro-benzylamino)-thiazol-4-one. LC-MS m/e 259 (MH+).

Sources & evidence

ORD record
ord-26ca6e323b3c47bda99c583f50a3b29a
Source dataset
uspto-grants-2009_03
Patent number
US07501428B2

Reaction notes

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