Diisopropylethylamine → HCID 178516940, compound

HRID 1783640Notes

Reaction equation

HRID 1783640 reaction equation
[Cl:1][C:2]1[CH:9]=[C:8]([F:10])[CH:7]=[CH:6][C:3]=1[CH2:4][NH2:5].[S:11]1[CH2:17][C:15](=[O:16])[NH:14][C:12]1=S.CCN(C(C)C)C(C)C>>[Cl:1][C:2]1[CH:9]=[C:8]([F:10])[CH:7]=[CH:6][C:3]=1[CH2:4][NH:5][C:12]1[S:11][CH2:17][C:15](=[O:16])[N:14]=1

Participants

4

Reactant 3

HCID 81531DiisopropylethylamineHCID 1399092-Chloro-4-fluorobenzylamineHCID 1201546Rhodanine

Product 1

HCID 178516940HCID 178516940, compound

Procedure

Similar procedure as described in example 15a was used, starting with 2-chloro-4-fluoro-benzylamine, rhodanine, mercuric chloride and DIEA to give 2-(2-chloro-4-fluoro-benzylamino)-thiazol-4-one. LC-MS m/e 259 (MH+).

Sources & evidence

ORD record
ord-74f8334e53e642c69aef0092773c67d0
Source dataset
uspto-grants-2009_03
Patent number
US07501428B2

Reaction notes

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