Methyl iodide → HCID 68896686, compound

HRID 1783677Notes

Reaction equation

HRID 1783677 reaction equation
C(OC([N:8]([C:26]1[CH:30]=[C:29]([CH3:31])[N:28](C(OC(C)(C)C)=O)[N:27]=1)[C:9]1[C:18]2[C:13](=[CH:14][C:15](C(O)=O)=[CH:16][CH:17]=2)[C:12](=[O:22])[N:11]([CH:23]([CH3:25])[CH3:24])[N:10]=1)=O)(C)(C)C.[C:39]([O-:42])([O-])=[O:40].[K+].[K+].[CH3:45]I>C(Cl)Cl>[CH3:45][O:42][C:39]([C:15]1[CH:14]=[C:13]2[C:18](=[CH:17][CH:16]=1)[C:9]([NH:8][C:26]1[CH:30]=[C:29]([CH3:31])[NH:28][N:27]=1)=[N:10][N:11]([CH:23]([CH3:25])[CH3:24])[C:12]2=[O:22])=[O:40]

Participants

5

Reactant 3

HCID 6328Methyl iodideHCID 11430Potassium CarbonateHCID 21106512HCID 21106512, compound

Product 1

HCID 68896686HCID 68896686, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

1-[tert-Butoxycarbonyl-(1-tert-butoxycarbonyl-5-methyl-1H-pyrazol-3-yl)-amino] -3-iso-propyl-4-oxo-3,4-dihydro-phthalazine-6-carboxylic acid (10 mg, 0.019 mmol) (Intermediate of Example M-1) was dissolved in DCM (1 ml). To this was added K2CO3 (3.1 mg, 0.028 mmol) followed by methyl iodide (3.3 mg, 0.028 mmol) and the reaction mixture was stirred at RT for 30 min. After this time the reaction mixture was partitioned between EtOAc (10 ml) and water (1:0 ml). The organic layer was separated, dried (MgSO4), filtered and concentrated under vacuum.

Workup

  1. customAfter this time the reaction mixture was partitioned between EtOAc (10 ml) and water (1:0 ml)
  2. customThe organic layer was separated
  3. dry with materialdried (MgSO4)
  4. filtrationfiltered
  5. concentrationconcentrated under vacuum

Sources & evidence

ORD record
ord-43a76ec34c624da5a3adf1c809658702
Source dataset
uspto-grants-2009_03
Patent number
US07501410B2

Reaction notes

Loading…