m-Chloroperbenzoic acid → HCID 21106518, compound

HRID 1783699Notes

Reaction equation

HRID 1783699 reaction equation
[Br:1][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[C:5](=[O:12])[N:4]([C:13]2[CH:18]=[CH:17][C:16]([S:19][C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=3)=[CH:15][CH:14]=2)[N:3]=1.C1C=C(Cl)C=C(C(OO)=[O:34])C=1>C(Cl)Cl>[C:20]1([S:19]([C:16]2[CH:17]=[CH:18][C:13]([N:4]3[N:3]=[C:2]([Br:1])[C:11]4[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=4)[C:5]3=[O:12])=[CH:14][CH:15]=2)=[O:34])[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1

Participants

4

Reactant 2

HCID 70297m-Chloroperbenzoic acidHCID 21106556HCID 21106556, compound

Product 1

HCID 21106518HCID 21106518, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

4-Bromo-2-(4-phenylsulfanyl-phenyl)-2H-phthalazin-1-one (0.095 g, 0.23 mmol) and MCPBA (0.052 g, 0.23 mmol) were stirred at RT in DCM (1 ml) for 1 h. The title compound was obtained after evaporation of the solvent in vacuum and subsequent purification of the raw product by chromatography over silica gel with heptane:DCM (1:1 until 0:1) (0.031 g, 31% yield). 1H-NMR: (400 MHz, CDCl3) 8.49 (1H, d), 7.80-7.99 (5H, m), 7.76 (2H, d), 7.69 (2H, d), 7.48 (3H, m); MS (ESI+)=427.22 (M+H)+.

Sources & evidence

ORD record
ord-82d629c958ce4a21bb12097c136b6ec0
Source dataset
uspto-grants-2009_03
Patent number
US07501410B2

Reaction notes

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