HCID 57433654, compound → HCID 68799518, compound

HRID 1783833Notes

Reaction equation

HRID 1783833 reaction equation
[C:1]([C:3]1[CH:4]=[C:5]([C:9]2[N:10]=[C:11]3[N:15]([C:16]=2[C:17](=[O:19])[CH3:18])[CH:14]=[CH:13][S:12]3)[CH:6]=[CH:7][CH:8]=1)#[N:2]>COC(OC)N(C)C>[CH3:14][N:15]([CH3:16])[CH:11]=[CH:18][C:17]([C:16]1[N:15]2[C:11]([S:12][CH:13]=[CH:14]2)=[N:10][C:9]=1[C:5]1[CH:6]=[CH:7][CH:8]=[C:3]([C:1]#[N:2])[CH:4]=1)=[O:19]

Participants

3

Reactant 1

HCID 57433654HCID 57433654, compound

Product 1

HCID 68799518HCID 68799518, compound

Reagents, catalysts & solvents 1

HCID 78373Dimethylformamide dimethyl acetalSolvent

Procedure

A 100 mL round bottom flask was charged with the 1-[6-(3-cyanophenyl)imidazo [2,1-b][1,3]thiazol-5-yl]ethanone (4.30 g, 16.1 mmol) and dimethylformamide dimethylacetal (40 mL). The mixture was refluxed for 6 hours and then concentrated in vacuo to provide a dark solid. LCMS: 323 [M+H]; purity: 90% by UV at 254 nm. This crude was used for next step reaction without further purification.

Workup

  1. temperatureThe mixture was refluxed for 6 hours
  2. concentrationconcentrated in vacuo
  3. customto provide a dark solid
  4. customThis crude was used for next step reaction without further purification

Sources & evidence

ORD record
ord-175172ecebcc4f3781a0057d35e58ec1
Source dataset
uspto-grants-2009_03
Patent number
US07501430B2

Reaction notes

Loading…