反应详情

温度

87.5 °C

1,7′-dimethyl-2′-propyl-1H,3′H-[2,5′]bibenzoimidazolyl (BIM) (4 g), Aliquat® 175 (1.36 ml), K2CO3 (8.19 g), and toluene (50 ml) were added to a 250 ml round bottom flask equipped with a magnetic stirring bar and reflux condenser. The mixture was heated to reflux (about 85-90° C.) until a clear brown organic solution was obtained. 4′bromomethyl-biphenyl-2-carboxylic acid (BMBP) methyl ester (4.5 g) in toluene (24 ml) was added to the clear brown organic solution to form a reaction mixture. The reaction mixture was stirred for about 6 hrs then cooled by ice bath and filtered forming a cooled reaction mixture. The cooled reaction mixture was then extracted twice with water (20 ml), dried over MgSO4, and evaporated forming telmisartan methyl ester (5.02 g), which is about a 69% yield.

1. customequipped with a magnetic stirring bar
2. temperaturereflux condenser
3. temperatureThe mixture was heated
4. customwas obtained
5. customto form a reaction mixture
6. temperaturethen cooled by ice bath
7. filtrationfiltered
8. customforming
9. customa cooled reaction mixture
10. customThe cooled reaction mixture
11. extractionwas then extracted twice with water (20 ml)
12. dry with materialdried over MgSO4
13. customevaporated