Ninhydrin → Afegostat

HRID 1784023Notes

Reaction equation

HRID 1784023 reaction equation
C(O)(C)C.[OH2:5].[NH4+:6].[OH-].C1C=[C:12]2[C:14]([C:16]([OH:20])(O)[C:17](=[O:18])[C:11]2=[CH:10]C=1)=O>>[CH2:10]1[NH:6][CH2:14][C@@H:16]([OH:20])[C@H:17]([OH:18])[C@H:11]1[CH2:12][OH:5]

Participants

3

Reactant 2

HCID 10236NinhydrinHCID 19893943isopropanol water NH4OH

Product 1

HCID 447607Afegostat

Procedure

TLC was performed on the different fractions (silica gel, isopropanol:water:NH4OH (7:2:1) and detection was via imino sugar and ninhydrin spray. Fractions testing positive with the imino-sugar sprays were analyzed to determine purity, then combined and lyophilized for 72 hours.

Sources & evidence

ORD record
ord-d6cc889528434fa396a38aa8ba73abe0
Source dataset
uspto-grants-2009_03
Patent number
US07501439B2

Reaction notes

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