Tetrahydrofuran → N-(4-chloro-5-iodo-7H-pyrrolo[2,3-d]pyrimidin-2-yl)pivalamide

HRID 178403Notes

Reaction equation

HRID 178403 reaction equation
[CH2:26]1[O:27][CH2:28][CH2:29][CH2:30]1.[Cl:1][c:2]1[c:3]2[c:4]([n:5][c:6]([NH:8][C:9]([C:10]([CH3:11])([CH3:12])[CH3:13])=[O:14])[n:7]1)[nH:15][cH:16][cH:17]2.[I:18][N:19]1[C:20](=[O:21])[CH2:22][CH2:23][C:24]1=[O:25]>>[Cl:1][c:2]1[c:3]2[c:4]([n:5][c:6]([NH:8][C:9]([C:10]([CH3:11])([CH3:12])[CH3:13])=[O:14])[n:7]1)[nH:15][cH:16][c:17]2[I:18]

Participants

4

Reactant 3

HCID 8028TetrahydrofuranHCID 120273N-IodosuccinimideHCID 11425285N-(4-Chloro-7H-pyrrolo[2,3-d]pyrimidin-2-yl)-2,2-dimethylpropionamide

Product 1

HCID 15484841N-(4-chloro-5-iodo-7H-pyrrolo[2,3-d]pyrimidin-2-yl)pivalamide

Sources & evidence

ORD record
ord-3fc493a2bdfe42169c32ea140cb44e32
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Reaction notes

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