Lithium hydroxide, monohydrate → HCID 53403819, compound

HRID 1784033Notes

Reaction equation

HRID 1784033 reaction equation
C[O:2][C:3]([CH:5]1[CH2:9][C:8](=[CH2:10])[CH2:7][CH:6]1[NH:11][C:12]([O:14][C:15]([CH3:18])([CH3:17])[CH3:16])=[O:13])=[O:4].O[Li].O>CO.O>[C:15]([O:14][C:12]([NH:11][CH:6]1[CH2:7][C:8](=[CH2:10])[CH2:9][CH:5]1[C:3]([OH:4])=[O:2])=[O:13])([CH3:18])([CH3:16])[CH3:17]

Participants

5

Reactant 2

HCID 168937Lithium hydroxide, monohydrateHCID 53403820HCID 53403820, compound

Product 1

HCID 53403819HCID 53403819, compoundYield 93.4%

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 962WaterSolvent

Procedure

To a solution of 1.28 g of 35a in 30 ml of MeOH was added a solution of 0.42 g of LiOH.H2O in 10 ml of H2O and stirring was continued at 50° C. for 1 h. The solution was evaporated to approximately half of the volume, the aqueous layer was washed with Et2O, acidified with HCl, the suspension was filtered and the residue dried to give 1.13 g (93%) of the title compound 35b. MS: 242.4 (M+H)+.

Workup

  1. customThe solution was evaporated to approximately half of the volume
  2. washthe aqueous layer was washed with Et2O
  3. filtrationthe suspension was filtered
  4. customthe residue dried

Sources & evidence

ORD record
ord-dd47680ab9c74cf5a2274334146045a8
Source dataset
uspto-grants-2009_03
Patent number
US07501413B2

Reaction notes

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