4-Bromo-2-fluoroaniline → 1-(4-amino-3-fluoro-phenyl)-4-benzyloxy-1H-pyridin-2-one

HRID 1784052Notes

Reaction equation

HRID 1784052 reaction equation
[CH2:1]([O:8][C:9]1[CH:14]=[CH:13][NH:12][C:11](=[O:15])[CH:10]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.Br[C:17]1[CH:23]=[CH:22][C:20]([NH2:21])=[C:19]([F:24])[CH:18]=1.NC1C=CC(N2C=CC=CC2=O)=CC=1F>>[NH2:21][C:20]1[CH:22]=[CH:23][C:17]([N:12]2[CH:13]=[CH:14][C:9]([O:8][CH2:1][C:2]3[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=3)=[CH:10][C:11]2=[O:15])=[CH:18][C:19]=1[F:24]

Participants

4

Reactant 3

HCID 1230504-Bromo-2-fluoroanilineHCID 36077244-Benzyloxy-2(1H)-pyridoneHCID 221815481-(4-Amino-3-fluorophenyl)pyridin-2-one

Product 1

HCID 668824131-(4-amino-3-fluoro-phenyl)-4-benzyloxy-1H-pyridin-2-one

Procedure

1-(4-Amino-3-fluoro-phenyl)-4-benzyloxy-1H-pyridin-2-one was prepared from 4-benzyloxy-1H-pyridin-2-one and 4-bromo-2-fluoroaniline in analogy to the procedure described for the preparation of 1-(4-amino-3-fluoro-phenyl)-1H-pyridin-2-one described in C. F. Bigge et al., patent application WO 2003045912. MS: 311 (M+H)+.

Sources & evidence

ORD record
ord-34c53b7818264de3813ba31788b88df6
Source dataset
uspto-grants-2009_03
Patent number
US07501413B2

Reaction notes

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