2-Methoxy-6-methylaniline → 9-Methoxy-2-(2-methoxy-6-methyl-phenylamino)-6,7-dihydro-pyrimido[6,1-a]isoquinolin-4-one

Participants

Role	Name	HCID	Charge
Reactant	2-Methoxy-6-methylaniline	HCID 459249	—
Reactant	2-chloro-9-methoxy-6,7-dihydro-4H-pyrimido[6,1-a]isoquinolin-4-one	HCID 57591093	—
Product	9-Methoxy-2-(2-methoxy-6-methyl-phenylamino)-6,7-dihydro-pyrimido[6,1-a]isoquinolin-4-one	HCID 11439895	—

Reaction Steps

The title compound was prepared from 2-chloro-9-methoxy-6,7-dihydro-pyrimido[6,1-a]isoquinolin-4-one (4) and 2-methoxy-6-methyl-aniline as in Example 1 d. 1H-NMR (400 MHz, d6-DMSO) δ 8.71 (br, 1H), 7.71 (br, 1H), 7.35-6.80 (5H), 6.39 (br, 1H), 3.92 (br, 2H), 3.83 (br, 3H), 3.74 (br, 3H), 2.94 (t, 2H) and 2.14 (br, 3H); MS (ESI) (M+H)+ 364.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07501512B2
Source dataset	uspto-grants-2009_03
ORD ID	ord-f48d66c02cb24b2da3b05215ca1ea5b0
Source note	uspto-grants-2009_03