1H-Indazol-6-amine → 2-(1H-Indazol-6-ylamino)-9-methoxy-6,7-dihydro-pyrimido[6,1-a]isoquinolin-4-one

Participants

Role	Name	HCID	Charge
Reactant	1H-Indazol-6-amine	HCID 81423	—
Reactant	2-chloro-9-methoxy-6,7-dihydro-4H-pyrimido[6,1-a]isoquinolin-4-one	HCID 57591093	—
Product	2-(1H-Indazol-6-ylamino)-9-methoxy-6,7-dihydro-pyrimido[6,1-a]isoquinolin-4-one	HCID 11210572	—

Reaction Steps

The title compound was prepared from 2-chloro-9-methoxy-6,7-dihydro-pyrimido[6,1-a]isoquinolin-4-one (4) and 1H-indazol-6-ylamine as in Example 1 d. 1H-NMR (400 MHz, d6-DMSO) δ 12.95 (br, 1H), 9.76 (s, 1H), 8.60 (s, 1H), 7.96 (s, 1H), 7.72-7.60 (2H), 7.15-6.95 (3H), 6.42 (s, 1H), 4.01 (t, 2H), 3.85 (s, 3H) and 2.98 (t, 2H); MS (ESI) (M+H)+ 360.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07501512B2
Source dataset	uspto-grants-2009_03
ORD ID	ord-2634d225563c4a6a92ea2b62881e43a7
Source note	uspto-grants-2009_03