Ethyl 3-aminobenzoate → HCID 57591101, compound

HRID 1784075Notes

Reaction equation

HRID 1784075 reaction equation
Cl[C:2]1[CH:17]=[C:6]2[C:7]3[C:12]([CH2:13][CH2:14][N:5]2[C:4](=[O:18])[N:3]=1)=[CH:11][C:10]([O:15][CH3:16])=[CH:9][CH:8]=3.[CH2:19]([O:21][C:22](=[O:30])[C:23]1[CH:28]=[CH:27][CH:26]=[C:25]([NH2:29])[CH:24]=1)[CH3:20]>>[CH2:19]([O:21][C:22](=[O:30])[C:23]1[CH:28]=[CH:27][CH:26]=[C:25]([NH:29][C:2]2[CH:17]=[C:6]3[C:7]4[C:12]([CH2:13][CH2:14][N:5]3[C:4](=[O:18])[N:3]=2)=[CH:11][C:10]([O:15][CH3:16])=[CH:9][CH:8]=4)[CH:24]=1)[CH3:20]

Participants

3

Reactant 2

HCID 11400Ethyl 3-aminobenzoateHCID 575910932-chloro-9-methoxy-6,7-dihydro-4H-pyrimido[6,1-a]isoquinolin-4-one

Product 1

HCID 57591101HCID 57591101, compound

Procedure

The title compound was prepared from 2-chloro-9-methoxy-6,7-dihydro-pyrimido[6,1-a]isoquinolin-4-one (4) and 3-amino-benzoic acid ethyl ester as in Example 1 d. 1H-NMR (400 MHz, d0-DMSO) δ 9.84 (s, 1H), 8.26 (s, 1H), 8.21 (d, 1H), 7.70 (d, 1H), 7.62 (d, 1H), 7.49 (t, 1H), 7.05-6.97 (2H), 6.36 (s, 1H), 4.33 (q, 2H), 3.99 (t, 2H), 3.85 (s, 3H), 2.97 (t, 2H) and 1.34 (t, 3H); MS (ESI) (M+H)+ 392.

Sources & evidence

ORD record
ord-d9f835ed430e4e08ae863940294eabf6
Source dataset
uspto-grants-2009_03
Patent number
US07501512B2

Reaction notes

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