N,N-Dimethylethylenediamine → HCID 11483848, compound

HRID 1784084Notes

Reaction equation

HRID 1784084 reaction equation
Cl[C:2]1[CH:17]=[C:6]2[C:7]3[C:12]([CH2:13][CH2:14][N:5]2[C:4](=[O:18])[N:3]=1)=[CH:11][C:10]([O:15][CH3:16])=[CH:9][CH:8]=3.[CH3:19][N:20]([CH3:24])[CH2:21][CH2:22][NH2:23]>>[CH3:19][N:20]([CH3:24])[CH2:21][CH2:22][NH:23][C:2]1[CH:17]=[C:6]2[C:7]3[C:12]([CH2:13][CH2:14][N:5]2[C:4](=[O:18])[N:3]=1)=[CH:11][C:10]([O:15][CH3:16])=[CH:9][CH:8]=3

Participants

3

Reactant 2

HCID 66053N,N-DimethylethylenediamineHCID 575910932-chloro-9-methoxy-6,7-dihydro-4H-pyrimido[6,1-a]isoquinolin-4-one

Product 1

HCID 11483848HCID 11483848, compound

Procedure

The title compound was prepared from 2-chloro-9-methoxy-6,7-dihydro-pyrimido[6,1-a]isoquinolin-4-one (4) and 2-dimethylamino-ethylamine as in Example 1 d. 1H-NMR (400 MHz, d6-DMSO) δ 7.81 (br, 1H), 7.78 (d, 1H), 7.01-6.95 (2H), 6.16 (s, 1H), 3.94 (t, 2H), 3.83 (s, 3H), 3.62 (br, 2H), 3.21 (br, 2H), 2.93 (t, 2H) and 2.83 (s, 6H); MS (ESI) (M+H)+ 315.

Sources & evidence

ORD record
ord-7111dc4b01da4ae5b296add8e13344e3
Source dataset
uspto-grants-2009_03
Patent number
US07501512B2

Reaction notes

Loading…