HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethanolamine → 2-(2-Hydroxy-ethylamino)-9-methoxy-6,7-dihydro-pyrimido[6,1-a]isoquinolin-4-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethanolamine | HCID 700 | — |
| Reactant | 2-chloro-9-methoxy-6,7-dihydro-4H-pyrimido[6,1-a]isoquinolin-4-one | HCID 57591093 | — |
| Solvent | Water | HCID 962 | — |
| Product | 2-(2-Hydroxy-ethylamino)-9-methoxy-6,7-dihydro-pyrimido[6,1-a]isoquinolin-4-one | HCID 11300670 | — |
Reaction Steps
The title compound was prepared from 2-chloro-9-methoxy-6,7-dihydro-pyrimido[6,1-a]isoquinolin-4-one (4) and 2-hydroxy-ethylamine as in Example 1 d. 1H-NMR (400 MHz, d6-DMSO) δ 7.62 (d 1H), 7.54 (t, 1H), 7.00-6.93 (2H), 6.17 (s, 1H), 4.85 (t, 1H), 3.91 (t, 2H), 3.82 (s, 3H) 3.50 (q, 2H), 2.91 (t, 2H) and 2H were overlapped with H2O; MS (ESI) (M+H)+ 288.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07501512B2 |
| Source dataset | uspto-grants-2009_03 |
| ORD ID | ord-39bcad5e35974ea09b9fa16f04031455 |
| Source note | uspto-grants-2009_03 |