HCID 57591440, compound → N-(3,4-Dimethoxy-phenyl)-2-phenyl-N-[2-(4-trifluoromethyl-phenyl)-ethyl]-malonamic acid

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Reaction Steps

0.35 g (0.62 mmol) N-(3,4-Dimethoxy-phenyl)-2-phenyl-N-[2-(4-trifluoromethyl-phenyl)-ethyl]-malonamic acid benzyl ester in 20 mL ethyl acetate and 0.37 mL acetic acid was hydrogenated over Pd/C with atmospheric pressure of H2 for 16 h at room temperature. The catalyst was filtered off and the and the filtrate evaporated to dryness. The acid was used without further purification in the consecutive step. MS(m/e): 488.2 (MH+).

Provenance & Evidence