Hydrochloric Acid → HCID 67530606, compound

HRID 17842Notes

Reaction equation

HRID 17842 reaction equation
N[C:2]1[CH:17]=[CH:16][C:5]2[N:6]([CH:12]3[CH2:15][CH2:14][CH2:13]3)[CH:7]=[N:8][S:9](=[O:11])(=[O:10])[C:4]=2[CH:3]=1.N([O-])=O.[Na+].O.[ClH:23]>>[Cl:23][C:2]1[CH:17]=[CH:16][C:5]2[N:6]([CH:12]3[CH2:15][CH2:14][CH2:13]3)[CH:7]=[N:8][S:9](=[O:11])(=[O:10])[C:4]=2[CH:3]=1

Participants

5

Reactant 4

HCID 313Hydrochloric Acid2×HCID 962WaterHCID 23668193Sodium NitriteHCID 675303087-amino-4-cyclobutyl-4H-1,2,4-benzothiadiazine 1,1-dioxide

Product 1

HCID 67530606HCID 67530606, compound

Procedure

A solution of 7-amino-4-cyclobutyl-4H-1,2,4-benzothiadiazine 1,1-dioxide prepared in the Step above (3.48 g) in 6N HCl (40 mL) is cooled on an ice bath and then an aqueous solution of NaNO2 (2 g in 15 mL) is added dropwise. The solution obtained is added gradually to a solution of the Cu2Cl2 in concentrated HCl (30 mL). After stirring for 30 minutes at ambient temperature, water (150 mL) is added to the reaction mixture and the precipitate obtained is collected by filtration, washed with water and dried.

Workup

  1. temperatureis cooled on an ice bath
  2. customThe solution obtained
  3. customthe precipitate obtained
  4. filtrationis collected by filtration
  5. washwashed with water
  6. customdried

Sources & evidence

ORD record
ord-4f0d747999b843099eb58febade47f8f
Source dataset
uspto-grants-2010_06
Patent number
US07741320B2

Reaction notes

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