(3-Bromophenoxy)(tert-butyl)dimethylsilane → 7-(3-t-Butyldimethysilyloxyphenylsulfonyl)-1,2,4,5-tetrahydro-3-benzazepine

HRID 1784398Notes

Reaction equation

HRID 1784398 reaction equation
FC(F)(F)C([N:5]1[CH2:11][CH2:10][C:9]2[CH:12]=[CH:13][C:14]([S:16](F)(=[O:18])=[O:17])=[CH:15][C:8]=2[CH2:7][CH2:6]1)=O.[Si:22]([O:29][C:30]1[CH:31]=[C:32](Br)[CH:33]=[CH:34][CH:35]=1)([C:25]([CH3:28])([CH3:27])[CH3:26])([CH3:24])[CH3:23]>>[Si:22]([O:29][C:30]1[CH:31]=[C:32]([S:16]([C:14]2[CH:13]=[CH:12][C:9]3[CH2:10][CH2:11][NH:5][CH2:6][CH2:7][C:8]=3[CH:15]=2)(=[O:17])=[O:18])[CH:33]=[CH:34][CH:35]=1)([C:25]([CH3:28])([CH3:27])[CH3:26])([CH3:24])[CH3:23]

Participants

3

Reactant 2

HCID 11254705(3-Bromophenoxy)(tert-butyl)dimethylsilaneHCID 575924833-Trifluoroacetyl-1,2,4,5-tetrahydro-3-benzazepine-7-sulfonyl fluoride

Product 1

HCID 688595047-(3-t-Butyldimethysilyloxyphenylsulfonyl)-1,2,4,5-tetrahydro-3-benzazepineYield 80%

Procedure

Prepared from 3-trifluoroacetyl-2,3,4,5-tetrahydro-1H-3-benzazepine-7-sulfonyl fluoride and 3-t-butyldimethylsilyloxybromobenzene using the method of Example 1, yield 80%.

Sources & evidence

ORD record
ord-cfc0c3931452434e99dfef546e8575c2
Source dataset
uspto-grants-2009_03
Patent number
US07504392B2

Reaction notes

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