反应详情

A mixture of 0.097 g (0.33 mmol) of the product from Step 7 (23) and 0.02 g of Palladium on activated carbon was stirred in 5 mL of ethyl acetate. The flask was equipped with a balloon containing hydrogen gas and the reaction mixture was stirred at ambient temperature for 3 days. The reaction mixture was then filtered through celite and washed with ethyl acetate. The resulting organic mixture was concentrated yielding 0.084 g (0.28 mmol, 85%) of 3-benzyl-2-(1-hydroxypropyl)-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-one (24) as a clear oil.

1. customThe flask was equipped with a balloon
2. filtrationThe reaction mixture was then filtered through celite
3. washwashed with ethyl acetate
4. concentrationThe resulting organic mixture was concentrated