Hydrochloric Acid → HCID 53628933, compound

HRID 1784654Notes

Reaction equation

HRID 1784654 reaction equation
[ClH:1].[F:2][C:3]1[CH:8]=[CH:7][C:6]([CH:9]2[CH2:14][N:13]([C:15]3[N:20]([CH3:21])[C:19](=[O:22])[CH:18]=[C:17]([C:23]4[CH:28]=[CH:27][N:26]=[CH:25][CH:24]=4)[N:16]=3)[CH2:12][CH2:11][NH:10]2)=[C:5]([O:29][CH3:30])[CH:4]=1.C(OCC)C>O1CCOCC1.ClCCl>[ClH:1].[ClH:1].[F:2][C:3]1[CH:8]=[CH:7][C:6]([CH:9]2[CH2:14][N:13]([C:15]3[N:20]([CH3:21])[C:19](=[O:22])[CH:18]=[C:17]([C:23]4[CH:24]=[CH:25][N:26]=[CH:27][CH:28]=4)[N:16]=3)[CH2:12][CH2:11][NH:10]2)=[C:5]([O:29][CH3:30])[CH:4]=1

Participants

6

Reactant 3

HCID 313Hydrochloric AcidHCID 3283Diethyl EtherHCID 11176902HCID 11176902, compound

Product 1

HCID 53628933HCID 53628933, compound

Reagents, catalysts & solvents 2

HCID 6344DichloromethaneSolventHCID 312751,4-DioxaneSolvent

Procedure

4N Hydrogen chloride in 1,4-dioxane (0.4 ml) was added to the solution of 2-(2-(4-fluoro-2-methoxyphenyl)piperazin-4-yl)-3-methyl-6-(4-pyridyl)-pyrimidin-4-one (217 mg, 0.6 mmol) in dichloromethane (5 ml) and stirred for 15 min. After addition of diethyl ether, filtration and wash with diethyl ether and dryness gave the title compound (260 mg, quant.).

Workup

  1. washwash with diethyl ether and dryness

Sources & evidence

ORD record
ord-2defdc061a3e4af19d2074b117bdb250
Source dataset
uspto-grants-2009_03
Patent number
US07504411B2

Reaction notes

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