2-Butanone, 3-bromo- → 2,3-Dimethyl-6-nitroimidazo[1,2-a]pyridine

HRID 1784728Notes

Reaction equation

HRID 1784728 reaction equation
Br[CH:2]([CH3:6])[C:3](=O)[CH3:4].[NH2:7][C:8]1[CH:13]=[CH:12][C:11]([N+:14]([O-:16])=[O:15])=[CH:10][N:9]=1>C(OCC)(=O)C>[CH3:4][C:3]1[N:7]=[C:8]2[CH:13]=[CH:12][C:11]([N+:14]([O-:16])=[O:15])=[CH:10][N:9]2[C:2]=1[CH3:6]

Participants

4

Reactant 2

HCID 131422-Butanone, 3-bromo-HCID 778882-Amino-5-nitropyridine

Product 1

HCID 231205232,3-Dimethyl-6-nitroimidazo[1,2-a]pyridine

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

Operations similar to Production Example 1-(2) were conducted using 3-bromo-2-butanone and 2-amino-5-nitropyridine. The solid whereupon obtained was suspended in ethyl acetate, and washed with saturated aqueous sodium hydrogencarbonate. After concentration under reduced pressure, the residue was recrystallized from ethanol to provide the title compound as yellow crystals.

Workup

  1. customThe solid whereupon obtained
  2. washwashed with saturated aqueous sodium hydrogencarbonate
  3. concentrationAfter concentration under reduced pressure
  4. customthe residue was recrystallized from ethanol

Sources & evidence

ORD record
ord-ddf90a8fa25e4e26a87c88dcaf38753b
Source dataset
uspto-grants-2009_03
Patent number
US07504412B2

Reaction notes

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