Ethyl bromopyruvate → Ethyl 6-nitroimidazo(1,2-a)pyridine-2-carboxylate

HRID 1784730Notes

Reaction equation

HRID 1784730 reaction equation
Br[CH2:2][C:3](=O)[C:4]([O:6][CH2:7][CH3:8])=[O:5].[NH2:10][C:11]1[CH:16]=[CH:15][C:14]([N+:17]([O-:19])=[O:18])=[CH:13][N:12]=1>C(OCC)(=O)C>[N+:17]([C:14]1[CH:15]=[CH:16][C:11]2[N:12]([CH:2]=[C:3]([C:4]([O:6][CH2:7][CH3:8])=[O:5])[N:10]=2)[CH:13]=1)([O-:19])=[O:18]

Participants

4

Reactant 2

HCID 66144Ethyl bromopyruvateHCID 778882-Amino-5-nitropyridine

Product 1

HCID 12558381Ethyl 6-nitroimidazo(1,2-a)pyridine-2-carboxylate

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

Operations similar to Production Example 1-(2) were conducted using ethyl bromopyruvate and 2-amino-5-nitropyridine. The solid whereupon obtained was suspended in ethyl acetate, and washed with saturated aqueous sodium hydrogencarbonate to provide the title compound as brown solid.

Workup

  1. customThe solid whereupon obtained
  2. washwashed with saturated aqueous sodium hydrogencarbonate

Sources & evidence

ORD record
ord-7accd1d7f1664bb3b1f3bc86e215ca2e
Source dataset
uspto-grants-2009_03
Patent number
US07504412B2

Reaction notes

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