反应详情

Operations similar to Production Example 1-(2) were conducted using methyl 3-bromo-2-oxobutanoate and 2-amino-5-nitropyridine. The resulting solid was suspended in ethyl acetate, washed with saturated aqueous sodium hydrogencarbonate solution and purified by silica gel column chromatography (hexane/ethyl acetate=2/1) to provide the title compound as yellow crystals.

1. washwashed with saturated aqueous sodium hydrogencarbonate solution
2. custompurified by silica gel column chromatography (hexane/ethyl acetate=2/1)