4-Bromo-3-methylbenzoic acid → 2-Methyl-4'-(trifluoromethyl)[1,1'-biphenyl]-4-carboxylic acid

HRID 1784736Notes

Reaction equation

HRID 1784736 reaction equation
[F:1][C:2]([F:13])([F:12])[C:3]1[CH:8]=[CH:7][C:6](B(O)O)=[CH:5][CH:4]=1.Br[C:15]1[CH:20]=[CH:19][C:18]([C:21]([OH:23])=[O:22])=[CH:17][C:16]=1[CH3:24]>>[CH3:24][C:16]1[CH:17]=[C:18]([C:21]([OH:23])=[O:22])[CH:19]=[CH:20][C:15]=1[C:6]1[CH:7]=[CH:8][C:3]([C:2]([F:13])([F:12])[F:1])=[CH:4][CH:5]=1

Participants

3

Reactant 2

HCID 821314-Bromo-3-methylbenzoic acidHCID 27343894-(Trifluoromethyl)phenylboronic acid

Product 1

HCID 231205192-Methyl-4'-(trifluoromethyl)[1,1'-biphenyl]-4-carboxylic acid

Procedure

Production Example 14 was repeated except that 4-(trifluoromethyl)phenylboronic acid and 4-bromo-3-methylbenzenecarboxylic acid were used, to provide the title compound as white solid.

Sources & evidence

ORD record
ord-75fa72349d064702bc2f10d81a0d521d
Source dataset
uspto-grants-2009_03
Patent number
US07504412B2

Reaction notes

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