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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1784736Generated: October 30, 2026

4-Bromo-3-methylbenzoic acid → 2-Methyl-4'-(trifluoromethyl)[1,1'-biphenyl]-4-carboxylic acid

https://huagongshe.com/reaction/1784736

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-Bromo-3-methylbenzoic acidHCID 82131—
Reactant4-(Trifluoromethyl)phenylboronic acidHCID 2734389—
Product2-Methyl-4'-(trifluoromethyl)[1,1'-biphenyl]-4-carboxylic acidHCID 23120519—

Reaction Steps

Production Example 14 was repeated except that 4-(trifluoromethyl)phenylboronic acid and 4-bromo-3-methylbenzenecarboxylic acid were used, to provide the title compound as white solid.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07504412B2
Source datasetuspto-grants-2009_03
ORD IDord-75fa72349d064702bc2f10d81a0d521d
Source noteuspto-grants-2009_03