4-Carboxyphenylboronic Acid → 4-[5-(Difluoromethoxy)-2-pyridyl]benzenecarboxylic acid

HRID 1784743Notes

Reaction equation

HRID 1784743 reaction equation
[C:1]([C:4]1[CH:9]=[CH:8][C:7](B(O)O)=[CH:6][CH:5]=1)([OH:3])=[O:2].Br[C:14]1[CH:19]=[CH:18][C:17]([O:20][CH:21]([F:23])[F:22])=[CH:16][N:15]=1>>[F:22][CH:21]([F:23])[O:20][C:17]1[CH:18]=[CH:19][C:14]([C:7]2[CH:8]=[CH:9][C:4]([C:1]([OH:3])=[O:2])=[CH:5][CH:6]=2)=[N:15][CH:16]=1

Participants

3

Reactant 2

HCID 3121834-Carboxyphenylboronic AcidHCID 231205792-Bromo-5-(difluoromethoxy)pyridine

Product 1

HCID 231205134-[5-(Difluoromethoxy)-2-pyridyl]benzenecarboxylic acid

Procedure

Operations similar to those of Production Example 14 were conducted using 4-carboxyphenylboronic acid and 2-bromo-5-(difluoromethoxy)pyridine, to provide the title compound as white solid.

Sources & evidence

ORD record
ord-b62752ee596f4f8c86b7587014a8b2bd
Source dataset
uspto-grants-2009_03
Patent number
US07504412B2

Reaction notes

Loading…